Safest Medicine Among Painkillers – What Patients Should Know
- Dr. Karuturi Subrahmanyam
- Apr 30
- 3 min read
Updated: 6 days ago

Introduction
Painkillers, also known as analgesics, are medicines used to reduce or relieve pain. While many types of painkillers are available, not all are equally safe for everyone. Some may cause side effects or complications, especially with long-term use. Knowing which painkiller is safest can help you make better choices for everyday pain relief.
Which is the Safest Painkiller?
For most people, the safest painkiller for general use is Paracetamol (also known as Acetaminophen).
Why is Paracetamol Considered the Safest?
It is gentle on the stomach and does not cause acidity or ulcers.
It has fewer side effects compared to other painkillers.
It is safe for people of all ages, including children and the elderly (if taken in correct dose).
It can be safely used in pregnancy under a doctor’s advice.
It does not thin the blood, making it safer in people with bleeding problems.
When Should You Be Cautious?
Although paracetamol is generally safe, you should be careful:
If you take more than the recommended dose, it can damage the liver.
If you already have liver disease, always consult your doctor before use.
Never combine multiple medicines that contain paracetamol (such as cold and flu medications), as this may lead to overdose.
Other Common Painkillers and Their Risks
Ibuprofen, Diclofenac, Naproxen (NSAIDs):
These reduce pain and inflammation but can cause gastric ulcers, kidney damage, and increase blood pressure if used for long periods.
Aspirin:
Effective for pain and also used in heart patients, but it can cause stomach bleeding and is not safe for children.
Opioids (like tramadol, morphine):
These are strong painkillers used for severe pain, but they carry the risk of drowsiness, addiction, and constipation.
Tips for Safe Use of Painkillers
Always follow the prescribed dose and timing.
Do not mix painkillers without a doctor’s advice.
Avoid long-term use without medical supervision.
Inform your doctor about any liver, kidney, or stomach conditions before taking painkillers.
Natural Home Remedies to Decrease Pain
Here are some natural remedies that act as painkillers and may help reduce mild to moderate pain without pharmaceutical drugs:
1. Turmeric (Curcumin)
Use: Anti-inflammatory and antioxidant
How: Mix 1 tsp of turmeric in warm milk or water daily
Best for: Joint pain, arthritis, muscle soreness
2. Ginger
Use: Blocks inflammatory compounds (like prostaglandins)
How: Drink ginger tea or take raw ginger daily
Best for: Menstrual pain, sore throat, muscle pain
3. Clove
Use: Natural analgesic (eugenol compound)
How: Clove oil applied topically or chew a clove
Best for: Toothache, gum pain
4. Capsaicin (from Chili Peppers)
Use: Depletes substance P (a pain transmitter)
How: Apply capsaicin cream externally
Best for: Neuropathic pain, joint pain
5. Peppermint Oil
Use: Muscle relaxant and anti-inflammatory
How: Dilute and massage on painful area
Best for: Headaches, muscle pain, digestive cramps
6. Willow Bark
Use: Contains salicin (like aspirin)
How: As tea or supplement (consult doctor)
Best for: Back pain, arthritis
7. Magnesium-rich Foods
Use: Relaxes muscles and nerve function
Sources: Spinach, almonds, bananas, pumpkin seeds
Best for: Muscle cramps, migraines
8. Epsom Salt Bath
Use: High in magnesium
How: Add 1-2 cups to warm bath
Best for: Body ache, fibromyalgia
9. Acupuncture or Acupressure
Use: Stimulates natural endorphin release
Best for: Chronic pain, migraines, joint disorders
10. Cold or Heat Therapy
Use: Numbs pain or improves blood flow
Best for: Sprains, strains, muscle injuries
Summary
Paracetamol is the safest choice among over-the-counter painkillers when taken at the right dose. It is effective for mild to moderate pain such as headaches, fever, toothache, and joint pains. For stronger pain or long-term use, always consult your doctor for the best and safest option tailored to your health needs.
Dr. Karuturi Subrahmanyam, MD, FRCP (London), FACP (USA)
Internal Medicine Specialist
Kify Hospital
Danavaipeta
Rajahmundry
Phone : 85000 23456
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