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  • Writer's pictureDr. Karuturi Subrahmanyam

Sirtuins and Aging


Aging is a complex process that involves many factors, such as genetics, environment, lifestyle, and metabolism. Aging can lead to various diseases and impairments, such as cognitive decline, cancer, diabetes, and cardiovascular problems. However, aging is not inevitable, and there are ways to slow down or even reverse some of its effects. One of the key players in the regulation of aging is a family of proteins called sirtuins.


Sirtuins are enzymes that can remove or add chemical groups called acetyl groups to other proteins, thereby changing their function. Sirtuins can affect many aspects of cellular function, such as gene expression, DNA repair, energy metabolism, oxidative stress, inflammation, and cell death. Sirtuins can also sense and respond to the levels of a molecule called NAD+, which is essential for energy production and cellular health.


Sirtuins have been found to be a critical factor in the regulation of aging and disease. Studies have shown that sirtuins can extend the lifespan of various organisms, such as yeast, worms, flies, mice, and even humans. Sirtuins can also protect against age-related diseases, such as Alzheimer’s and Parkinson’s diseases, diabetes, and cardiovascular diseases. Sirtuins can modulate the activity of certain genes and pathways that are involved in aging and disease, such as FOXO3 and NF-κB.


One of the ways to activate sirtuins is through fasting and exercise. Some natural compounds, such as resveratrol, pterostilbene, fisetin, and curcumin, can mimic the effects of calorie restriction, which is known to extend lifespan and healthspan. These compounds can increase the levels of NAD+ and sirtuin activity in the cells, which can then enhance cellular function and resilience. Exercise can also increase sirtuin activity by stimulating NAD+ production and improving blood flow.

Sirtuins are a promising target for anti-aging interventions. By activating sirtuins or increasing NAD+ levels, we may be able to delay or prevent some of the negative effects of aging and improve our quality of life.


However, more research is needed to understand the exact mechanisms and optimal doses of sirtuin activators for different conditions and individuals.


Dr. Karuturi Subrahmanyam, MD, FRCP (London), FACP (USA)

Internal Medicine Specialist


Kify Hospital

Danavaipeta

Rajahmundry

Phone : 85000 23456

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